Molecular and extract-based diagnostics in meat allergy. In Molecular allergy diagnostics: Innovation for a better patient management. (Book Chapter)

  • Molecular and Translational Allergology
May 09, 2017 By:
  • Hilger C
  • Hemmer W
  • Swoboda I
  • Morisset M
  • Fischer J
  • Tripathi A
  • Platts-Mills T
  • Biedermann T.

Allergy to meat has come into the focus of research during the last years. This chapter introduces the different types of meat allergy such as pork-cat and bird-egg syndrome, genuine poultry meat allergy, and type I reactions to galactose-α-1,3-galactose (α-Gal) in red meat allergy. pork-cat and bird-egg syndrome are triggered by sensitization to aeroallergens such as animal dander and bird feathers containing serum albumins, which are heat-sensitive allergens. In contrast, genuine poultry meat allergy is a consequence of sensitization to heat-resistant meat allergens, most likely via the intestinal mucosa. The α-Gal syndrome is characterized by the presence of IgE antibodies to α-Gal, a delayed onset of symptoms, and a possible acceleration or aggravation of symptoms by cofactors. Diagnosis using whole extracts cannot discriminate between these different types of allergy; however, molecular allergen diagnostic tools are available that allow an accurate diagnosis. Clinical practice and recommendations for the patients regarding allergen avoidance and dietary restriction are discussed.

2017 May. Kleine-Tebbe J and Jakob T, eds. Cham: Springer International Publishing, 2017. p.305-326. ISBN 978-3-319-42498-9; 978-3-319-42499-6.
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