New MR perfusion features in primary central nervous system lymphomas: pattern and prognostic impact.

  • Luxembourg Center of Neuropathology
March 01, 2018 By:
  • Blasel S
  • Vorwerk R
  • Kiyose M
  • Mittelbronn M
  • Brunnberg U
  • Ackermann H
  • Voss M
  • Harter PN
  • Hattingen E.

PURPOSE: Some MR perfusion features predict overall survival (OS) and progression-free survival (PFS) in glioblastomas. Prognostic value of MR perfusion in primary CNS lymphomas (PCNSL) remains unexplored being the aim of this investigation. METHODS: We retrospectively analyzed 3Tesla dynamic susceptibility contrast MR perfusion in 37 pre-surgical PCNSL for normalized regional cerebral blood volume rCBVmean and rCBVmax and for a PCNSL-typical shoulder-like increase of the time-signal intensity curve ("TSIC-shoulder"), indicating moderate vessel permeability. These MR perfusion features, tumor and edema size, number of lesions and patient characteristics were correlated with OS and PFS. RESULTS: Only patient's age was prognostic for OS (p = 0.0037) and PFS (p = 0.0088). 23 PCNSL had the TSIC-shoulder, a middle-sized diameter (39.5 +/- 10.8 mm), volume (15.7 +/- 11.3 ml), peritumoral edema (23 +/- 8.7 mm) and moderately increased rCBVmean and rCBVmax (1.7 +/- 0.5; 3.9 +/- 1.2). Seven PCSNL with the TSIC-shoulder presented a sun-like pattern ("rCBV-sun") with a rim of marginally high rCBV. These unifocal PCNSL were larger (43 +/- 11.2 mm; 25.62 +/- 19.2 ml), with more peritumoral edema (32.8 +/- 7.6 mm) and lower CBVmean (0.8 +/- 0.3) and rCBVmax (2.2 +/- 0.7), compared to the remaining six multifocal PCNSL without the TSIC-shoulder (26.3 +/- 8.3 mm; 4.7 +/- 4 ml; 16.3 +/- 6.4 mm; 2.4 +/- 1.6; 4.4 +/- 2.3). CONCLUSIONS: Only patient age was predictive for OS and PFS of PCNSL; MR perfusion parameters and features were not. Most PCNSL revealed the TSIC-shoulder, moderate size, peritumoral edema and rCBV increase. However, larger, solitary PCNSL additionally had a rCBV-sun pattern and more edema, maybe due to a centrifugal vessel proliferation, whereas smaller, multifocal PCNSL contain apparently more concentrated and less permeable blood vessels represented by higher rCBV, no TSIC-shoulder and less edema.

2018 Mar. J Neurol.265(3):647-658. Epub 2018 Jan 30.
Other information