Andy Chevigne

Latest publications

CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems.

  • Immuno-Pharmacology and Interactomics
October 05, 2020
2020 Oct. Front Immunol.11:561404.
By:
  • Kouzeli A
  • Collins PJ
  • Metzemaekers M
  • Meyrath M
  • Szpakowska M
  • Artinger M
  • Struyf S
  • Proost P
  • Chevigne A
  • Legler DF
  • Eberl M
  • Moser B.

GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of G(s) and G(q/11).

  • Immuno-Pharmacology and Interactomics
September 21, 2020
2020 Sep. Nat Commun.11(1):4752.
By:
  • Abboud D
  • Daly AF
  • Dupuis N
  • Bahri MA
  • Inoue A
  • Chevign√© A
  • Ectors F
  • Plenevaux A
  • Pirotte B
  • Beckers A
  • Hanson J.

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides.

  • Immuno-Pharmacology and Interactomics
  • Immune Endocrine and Epigenetics
  • Transversal Translational Medicine
  • Allergy and Clinical Immunology
June 19, 2020
2020 Jun. Nat Commun.11(1):3033.
By:
  • Meyrath M
  • Szpakowska M
  • Zeiner J
  • Massotte L
  • Merz MP
  • Benkel T
  • Simon K
  • Ohnmacht J
  • Turner JD
  • Kruger R
  • Seutin V
  • Ollert M
  • Kostenis E
  • Chevigne A.

Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22.

  • Immuno-Pharmacology and Interactomics
June 01, 2020
2020 Jun. J Leukoc Biol. Online ahead of print.
By:
  • Meyrath M
  • Reynders N
  • Uchanski T
  • Chevigne A
  • Szpakowska M.

Assessment of biased agonism among distinct synthetic cannabinoid receptor agonist scaffolds.

  • Immuno-Pharmacology and Interactomics
April 10, 2020
2020 Apr. ACS Pharmacol Transl Sci.3(2):285-295.
By:
  • Wouters E
  • Walraed J
  • Robertson MJ
  • Meyrath M
  • Szpakowska M
  • Chevigne A
  • Skiniotis G
  • Stove C.

Structural features of an extended C-terminal tail modulate function of the chemokine CCL21.

  • Immuno-Pharmacology and Interactomics
April 07, 2020
2020 Apr. Biochemistry.59(13):1338-1350. Epub 2020 Mar 26.
By:
  • Moussouras NA
  • Hjorto GM
  • Peterson FC
  • Szpakowska M
  • Chevigne A
  • Rosenkilde MM
  • Volkman BF
  • Dwinell MB.

The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical relevance and therapy.

  • Immuno-Pharmacology and Interactomics
February 14, 2020
2020 Feb. Adv Cancer Res.145:99-138. Epub 2020 Feb 14.
By:
  • Sjoberg E
  • Meyrath M
  • Chevigne A
  • Ostman A
  • Augsten M
  • Szpakowska M.

The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein-protein interaction in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Multiomics Data Science
  • Immuno-Pharmacology and Interactomics
September 06, 2019
2019 Sep. Neurooncol Adv.1(1):vdz024.
By:
  • Neirinckx V
  • Hau AC
  • Schuster A
  • Fritah S
  • Tiemann K
  • Klein E
  • Nazarov PV
  • Matagne A
  • Szpakowska M
  • Meyrath M
  • Chevigne A
  • Schmidt MHH
  • Niclou SP.

Predominance of the heterozygous CCR5 delta-24 deletion in African individuals resistant to HIV infection might be related to a defect in CCR5 addressing at the cell surface.

  • HIV Clinical and Translational Research
  • Platform National Cytometry Platform
  • Immuno-Pharmacology and Interactomics
September 01, 2019
2019 Sep. J Int AIDS Soc.22(9):e25384.
By:
  • Arendt V
  • Amand M
  • Iserentant G
  • Lemaire M
  • Masquelier C
  • Ndayisaba GF
  • Verhofstede C
  • Karita E
  • Allen S
  • Chevigne A
  • Schmit JC
  • Bercoff DP
  • Seguin-Devaux C.

The distinct roles of CXCR3 variants and their ligands in the tumor microenvironment.

  • Immuno-Pharmacology and Interactomics
  • Tumor Immunotherapy and Microenvironment
  • NORLUX Neuro-Oncology Laboratory
June 18, 2019
2019 Jun. Cells.8(6).
By:
  • Reynders N
  • Abboud D
  • Baragli A
  • Noman MZ
  • Rogister B
  • Niclou SP
  • Heveker N
  • Janji B
  • Hanson J
  • Szpakowska M
  • Chevigne A.

A novel ACKR2-dependent role of fibroblast-derived CXCL14 in epithelial-to-mesenchymal transition and metastasis of breast cancer.

  • Immuno-Pharmacology and Interactomics
June 15, 2019
2019 Jun. Clin Cancer Res.25(12):3702-3717. Epub 2019 Mar 8.
By:
  • Sjoberg E
  • Meyrath M
  • Milde L
  • Herrera M
  • Lovrot J
  • Hagerstrand D
  • Frings O
  • Bartish M
  • Rolny C
  • Sonnhammer E
  • Chevigne A
  • Augsten M
  • Ostman A.

Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration.

  • Immuno-Pharmacology and Interactomics
January 01, 2019
2019 Jan. Oncogene.38(1):73-87. Epub 2018 Aug 6.
By:
  • Willems E
  • Dedobbeleer M
  • Digregorio M
  • Lombard A
  • Goffart N
  • Lumapat PN
  • Lambert J
  • Van den Ackerveken P
  • Szpakowska M
  • Chevigne A
  • Scholtes F
  • Rogister B.

Driving cytotoxic natural killer cells into melanoma: If CCL5 plays the music, autophagy calls the shots.

  • Tumor Immunotherapy and Microenvironment
  • Immuno-Pharmacology and Interactomics
  • Allergy and Clinical Immunology
September 11, 2018
2018 Sep. Crit Rev Oncog.23(5-6):321-332.
By:
  • Xiao M
  • Noman MZ
  • Menard L
  • Chevigne A
  • Szpakowska M
  • Bosseler M
  • Ollert M
  • Berchem G
  • Janji B.

Emerging roles of the protease allergen Der p 1 in house dust mite-induced airway inflammation.

  • Immuno-Pharmacology and Interactomics
August 01, 2018
2018 Aug. J Allergy Clin Immunol.142(2):398-400. Epub 2018 Jun 12.
By:
  • Chevigne A
  • Jacquet A.

Development of Mimokines, chemokine N terminus-based CXCR4 inhibitors optimized by phage display and rational design.

  • Immuno-Pharmacology and Interactomics
  • HIV Clinical and Translational Research
August 01, 2018
2018 Aug. J Leukoc Biol.104(2):343-357. Epub 2018 Mar 23.
By:
  • Fievez V
  • Szpakowska M
  • Mosbah A
  • Arumugam K
  • Mathu J
  • Counson M
  • Beaupain N
  • Seguin-Devaux C
  • Deroo S
  • Baudy-Floc'h M
  • Chevigne A.

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.

  • Immuno-Pharmacology and Interactomics
July 01, 2018
2018 Jul. Biochem Pharmacol.153:299-309. Epub 2018 Mar 9.
By:
  • Szpakowska M
  • Meyrath M
  • Reynders N
  • Counson M
  • Hanson J
  • Steyaert J
  • Chevigne A.

Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.

  • Immuno-Pharmacology and Interactomics
May 01, 2018
2018 May. Br J Pharmacol.175(9):1419-1438. Epub 2018 Mar 23.
By:
  • Szpakowska M
  • Nevins AM
  • Meyrath M
  • Rhainds D
  • D'Huys T
  • Guite-Vinet F
  • Dupuis N
  • Gauthier PA
  • Counson M
  • Kleist A
  • St-Onge G
  • Hanson J
  • Schols D
  • Volkman BF
  • Heveker N
  • Chevigne A.

Profiling the extended cleavage specificity of the house dust mite protease allergens Der p 1, Der p 3 and Der p 6 for the prediction of new cell surface protein substrates.

  • Immuno-Pharmacology and Interactomics
June 27, 2017
2017 Jun. Int J Mol Sci.18(7).
By:
  • Jacquet A
  • Campisi V
  • Szpakowska M
  • Dumez ME
  • Galleni M
  • Chevigne A.

Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes beta-arrestin 2 recruitment.

  • Immuno-Pharmacology and Interactomics
June 01, 2017
2017 Jun. Mol Pharmacol.91(6):595-608. Epub 2017 Mar 17.
By:
  • Dupuis N
  • Laschet C
  • Franssen D
  • Szpakowska M
  • Gilissen J
  • Geubelle P
  • Soni A
  • Parent AS
  • Pirotte B
  • Chevigne A
  • Twizere JC
  • Hanson J.

The Lys-Asp-Tyr triad within the mite allergen Der p 1 propeptide is a critical structural element for the pH-dependent initiation of the protease maturation.

  • Immuno-Pharmacology and Interactomics
May 20, 2017
2017 May. Int J Mol Sci.18(5).
By:
  • Chevigne A
  • Campizi V
  • Szpakowska M
  • Bourry D
  • Dumez ME
  • Martins JC
  • Matagne A
  • Galleni M
  • Jacquet A.