Jérôme Paggetti

Latest publications

Method for the analysis of the tumor microenvironment by mass cytometry: Application to chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • Platform National Cytometry Platform
October 20, 2020
2020 Oct. Front Immunol.11:578176.
By:
  • Gonder S
  • Fernandez Botana I
  • Wierz M
  • Pagano G
  • Gargiulo E
  • Cosma A
  • Moussay E
  • Paggetti J
  • Largeot A.

Diagnostic and therapeutic potential of extracellular vesicles in B-cell malignancies.

  • Tumor Stroma Interactions
September 29, 2020
2020 Sep. Front Oncol.10(2057):580874.
By:
  • Gargiulo E
  • Morande PE
  • Largeot A
  • Moussay E
  • Paggetti J.

Hematological malignancy-derived small extracellular vesicles and tumor microenvironment: The art of turning foes into friends.

  • Tumor Stroma Interactions
May 27, 2019
2019 May. Cells.8(5):pii: E511.
By:
  • Gargiulo E
  • Paggetti J
  • Moussay E.

The B-side of cancer immunity: The underrated tune.

  • Tumor Stroma Interactions
May 13, 2019
2019 May. Cells.8(5):pii: E449.
By:
  • Largeot A
  • Pagano G
  • Gonder S
  • Moussay E
  • Paggetti J.

HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells.

  • Tumor Stroma Interactions
April 01, 2019
2019 Apr. Oncogene.38(15):2767-2777. Epub 2018 Dec 12.
By:
  • Causse SZ
  • Marcion G
  • Chanteloup G
  • Uyanik B
  • Boudesco C
  • Grigorash BB
  • Douhard R
  • Dias AMM
  • Dumetier B
  • Dondaine L
  • Gozzi GJ
  • Moussay E
  • Paggetti J
  • Mirjolet C
  • de Thonel A
  • Dubrez L
  • Demidov ON
  • Gobbo J
  • Garrido C.

Purification of leukemia-derived exosomes to study microenvironment modulation.

  • Tumor Stroma Interactions
  • Platform National Cytometry Platform
January 01, 2019
2019 Jan. Methods Mol Biol.1884:231-245.
By:
  • Wierz M
  • Pierson S
  • Gargiulo E
  • Guerin C
  • Moussay E
  • Paggetti J.

High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
May 24, 2018
2018 May. OncoImmunology.7(8):e1465167.
By:
  • Wierz M
  • Janji B
  • Berchem G
  • Moussay E
  • Paggetti J.

Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
April 25, 2018
2018 Apr. OncoImmunology.7(8):e1452583.
By:
  • Noman MZ
  • Paggetti J
  • Moussay E
  • Berchem G
  • Janji B.

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • Platform National Cytometry Platform
  • Tumor Immunotherapy and Microenvironment
  • NORLUX Neuro-Oncology Laboratory
  • Allergy and Clinical Immunology
April 05, 2018
2018 Apr. Blood.131(14):1617-1621. Epub 2018 Feb 13.
By:
  • Wierz M
  • Pierson S
  • Guyonnet L
  • Viry E
  • Lequeux A
  • Oudin A
  • Niclou SP
  • Ollert M
  • Berchem G
  • Janji B
  • Guerin C
  • Paggetti J
  • Moussay E.

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model.

  • Tumor Stroma Interactions
April 01, 2018
2018 Apr. Haematologica.103(4):e154-e157. Epub 2018 Jan 5.
By:
  • Wierz M
  • Pierson S
  • Chouha N
  • Desaubry L
  • Francois JH
  • Berchem G
  • Paggetti J
  • Moussay E.

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
  • Platform National Cytometry Platform
October 31, 2017
2017 Oct. Proc Natl Acad Sci U S A.114(44):E9271-E9279. Epub 2017 Oct 16.
By:
  • Mgrditchian T
  • Arakelian T
  • Paggetti J
  • Noman MZ
  • Viry E
  • Moussay E
  • Van Moer K
  • Kreis S
  • Guerin C
  • Buart S
  • Robert C
  • Borg C
  • Vielh P
  • Chouaib S
  • Berchem G
  • Janji B.

Tumor-derived exosomes modulate PD-L1 expression in monocytes.

  • Tumor Stroma Interactions
July 28, 2017
2017 Jul. Sci Immunol.2(13):pii: eaah5509.
By:
  • Haderk F
  • Schulz R
  • Iskar M
  • Cid LL
  • Worst T
  • Willmund KV
  • Schulz A
  • Warnken U
  • Seiler J
  • Benner A
  • Nessling M
  • Zenz T
  • Gobel M
  • Durig J
  • Diederichs S
  • Paggetti J
  • Moussay E
  • Stilgenbauer S
  • Zapatka M
  • Lichter P
  • Seiffert M.

Hijacker of the antitumor immune response: autophagy is showing its worst facet.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
November 18, 2016
2016 Nov. Front Oncol.6(246):246.
By:
  • Viry E
  • Noman MZ
  • Arakelian T
  • Lequeux A
  • Chouaib S
  • Berchem G
  • Moussay E
  • Paggetti J
  • Janji B.

The multifaceted role of autophagy in tumor evasion from immune surveillance.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
April 05, 2016
2016 Apr. Oncotarget.7(14):17591-607.
By:
  • Janji B
  • Viry E
  • Moussay E
  • Paggetti J
  • Arakelian T
  • Mgrditchian T
  • Messai Y
  • Noman MZ
  • Van Moer K
  • Hasmim M
  • Mami-Chouaib F
  • Berchem G
  • Chouaib S.

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-beta and miR23a transfer.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
April 01, 2016
2016 Apr. OncoImmunology.5(4):e1062968. Epub 2015 Jun 24.
By:
  • Berchem G
  • Noman MZ
  • Bosseler M
  • Paggetti J
  • Baconnais S
  • Le Cam E
  • Nanbakhsh A
  • Moussay E
  • Mami-Chouaib F
  • Janji B
  • Chouaib S.

BCR engagement in CLL: when translation goes wrong.

  • Tumor Stroma Interactions
January 28, 2016
2016 Jan. Blood.127(4):378-80.
By:
  • Paggetti J
  • Moussay E.

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
  • Proteomics of cellular signaling
August 27, 2015
2015 Aug. Blood.126(9):1106-17. Epub 2015 Jun 22.
By:
  • Paggetti J
  • Haderk F
  • Seiffert M
  • Janji B
  • Distler U
  • Ammerlaan W
  • Kim YJ
  • Adam J
  • Lichter P
  • Solary E
  • Berchem G
  • Moussay E.

Hypoxia: A key feature of the tumor microenvironment triggers several mechanisms of evasion from natural killer and cytotoxic T lymphocytes surveillance.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
  • Cytoskeleton and Cancer Progression
November 20, 2014
2014 Nov. J Imm Res.1(2):7.
By:
  • Mgrditchian T
  • Arakelian T
  • Paggetti J
  • Viry E
  • Al-Absi A
  • Medves S
  • Moussay E
  • Berchem G
  • Thomas C
  • Janji B.

Autophagy: An adaptive metabolic response to stress shaping the antitumor immunity.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
November 01, 2014
2014 Nov. Biochem Pharmacol.92(1):31-42. Epub 2014 Jul 17.
By:
  • Viry E
  • Paggetti J
  • Baginska J
  • Mgrditchian T
  • Berchem G
  • Moussay E
  • Janji B.

Hypoxia-induced autophagy in tumor cells: a key target for improving cancer immunotherapy.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
September 14, 2014
2014 Sep. Cancer Cell Microenviron.1(4):e213.
By:
  • Paggetti J
  • Viry E
  • Berchem G
  • Moussay E
  • Janji B.