Muhammad Zaeem Noman

Latest publications

Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34.

  • Tumor Immunotherapy and Microenvironment
November 01, 2020
2020 Nov. Autophagy.(11):2110-2111. Epub 2020 Sep 5.
By:
  • Janji B
  • Hasmim M
  • Parpal S
  • De Milito A
  • Berchem G
  • Noman MZ.

The 'Holy Grail' in immuno-oncology: AC BioScience SA is aiming to potentiate anti-PD-1 therapy efficacy through tumor cell conditioning strategy.

  • Tumor Immunotherapy and Microenvironment
October 28, 2020
2020 Oct. Chimia.74(10):771-775.
By:
  • Schlapfer A
  • Auclair C
  • Janji B
  • Karam M
  • Zaeem Noman M.

Firing up the cold tumors by targeting Vps34.

  • Tumor Immunotherapy and Microenvironment
August 31, 2020
2020 Aug. OncoImmunology.9(1):1809936.
By:
  • Janji B
  • Hasmim M
  • Parpal S
  • Berchem G
  • Noman MZ.

The emerging impact of autophagy on the antitumor immune response. In Autophagy in immune response: Impact on cancer immunotherapy. 1st ed. (Book Chapter)

  • Tumor Immunotherapy and Microenvironment
May 11, 2020
2020 May. Chouaib S, ed. London: Academic Press, 2020. p.109-117. (Sensitizing Agent-Canc Resistant-Cell Mediated Immtherap, Vol.1). ISBN 978-0-12-819609-0.
By:
  • Hasmim M
  • Xiao M
  • Viry E
  • Noman MZ
  • Duhem C
  • Berchem G
  • Janji B.

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy.

  • Tumor Immunotherapy and Microenvironment
May 01, 2020
2020 May. Sci Adv.6(18):eaax7881.
By:
  • Noman MZ
  • Parpal S
  • Van Moer K
  • Xiao M
  • Yu Y
  • Viklund J
  • De Milito A
  • Hasmim M
  • Andersson M
  • Amaravadi RK
  • Martinsson J
  • Berchem G
  • Janji B.

Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment: new opportunities and challenges.

  • Tumor Immunotherapy and Microenvironment
September 14, 2019
2019 Sep. Cells.8(9).
By:
  • Noman MZ
  • Hasmim M
  • Lequeux A
  • Xiao M
  • Duhem C
  • Chouaib S
  • Berchem G
  • Janji B.

Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints.

  • Tumor Immunotherapy and Microenvironment
August 28, 2019
2019 Aug. Cancer Lett.458:13-20. Epub 2019 May 25.
By:
  • Lequeux A
  • Noman MZ
  • Xiao M
  • Sauvage D
  • Van Moer K
  • Viry E
  • Bocci I
  • Hasmim M
  • Bosseler M
  • Berchem G
  • Janji B.

Driving cytotoxic natural killer cells into melanoma: If CCL5 plays the music, autophagy calls the shots.

  • Tumor Immunotherapy and Microenvironment
  • Immuno-Pharmacology and Interactomics
  • Allergy and Clinical Immunology
September 11, 2018
2018 Sep. Crit Rev Oncog.23(5-6):321-332.
By:
  • Xiao M
  • Noman MZ
  • Menard L
  • Chevigne A
  • Szpakowska M
  • Bosseler M
  • Ollert M
  • Berchem G
  • Janji B.

Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
April 25, 2018
2018 Apr. OncoImmunology.7(8):e1452583.
By:
  • Noman MZ
  • Paggetti J
  • Moussay E
  • Berchem G
  • Janji B.

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT.

  • Tumor Immunotherapy and Microenvironment
  • Computational Biomedicine
February 15, 2018
2018 Feb. OncoImmunology.7(4):e1345415.
By:
  • Noman MZ
  • Van Moer K
  • Marani V
  • Gemmill RM
  • Tranchevent LC
  • Azuaje F
  • Muller A
  • Chouaib S
  • Thiery JP
  • Berchem G
  • Janji B.

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
  • Platform National Cytometry
October 31, 2017
2017 Oct. Proc Natl Acad Sci U S A.114(44):E9271-E9279. Epub 2017 Oct 16.
By:
  • Mgrditchian T
  • Arakelian T
  • Paggetti J
  • Noman MZ
  • Viry E
  • Moussay E
  • Van Moer K
  • Kreis S
  • Guerin C
  • Buart S
  • Robert C
  • Borg C
  • Vielh P
  • Chouaib S
  • Berchem G
  • Janji B.

The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200.

  • Tumor Immunotherapy and Microenvironment
January 23, 2017
2017 Jan. OncoImmunology.6(1):e1263412.
By:
  • Noman MZ
  • Janji B
  • Abdou A
  • Hasmim M
  • Terry S
  • Tan TZ
  • Mami-Chouaib F
  • Thiery JP
  • Chouaib S.

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity.

  • Tumor Immunotherapy and Microenvironment
January 17, 2017
2017 Jan. OncoImmunology.6(2):e1271858.
By:
  • Terry S
  • Buart S
  • Tan TZ
  • Gros G
  • Noman MZ
  • Lorens JB
  • Mami-Chouaib F
  • Thiery JP
  • Chouaib S.

Hijacker of the antitumor immune response: autophagy is showing its worst facet.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
November 18, 2016
2016 Nov. Front Oncol.6(246):246.
By:
  • Viry E
  • Noman MZ
  • Arakelian T
  • Lequeux A
  • Chouaib S
  • Berchem G
  • Moussay E
  • Paggetti J
  • Janji B.

The multifaceted role of autophagy in tumor evasion from immune surveillance.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
April 05, 2016
2016 Apr. Oncotarget.7(14):17591-607.
By:
  • Janji B
  • Viry E
  • Moussay E
  • Paggetti J
  • Arakelian T
  • Mgrditchian T
  • Messai Y
  • Noman MZ
  • Van Moer K
  • Hasmim M
  • Mami-Chouaib F
  • Berchem G
  • Chouaib S.