Olivier Keunen

Latest publications

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Drug Discovery
October 03, 2020
2020 Oct. Acta Neuropathol. Online ahead of print.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.

Is there a prominent role for MR spectroscopy in the clinical management of brain tumors?

  • Translational Radiomics
  • NORLUX Neuro-Oncology Laboratory
July 01, 2020
2020 Jul. Neuro Oncol.22(7):903-904.
By:
  • Keunen O
  • Niclou SP.

Spatially regularized estimation of the tissue homogeneity model parameters in DCE-MRI using proximal minimization.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
December 01, 2019
2019 Dec. Magn Reson Med.82(6):2257-2272. Epub 2019 Jul 17.
By:
  • Bartos M
  • Rajmic P
  • Sorel M
  • Mangova M
  • Keunen O
  • Jirik R.

Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier.

  • Translational Radiomics
  • NORLUX Neuro-Oncology Laboratory
November 01, 2019
2019 Nov. Mol Cancer Ther.18(11):2171-2181. Epub 2019 Aug 29.
By:
  • Aasen SN
  • Espedal H
  • Holte CF
  • Keunen O
  • Karlsen TV
  • Tenstad O
  • Maherally Z
  • Miletic H
  • Hoang T
  • Eikeland AV
  • Baghirov H
  • Olberg DE
  • Pilkington GJ
  • Sarkar G
  • Jenkins RB
  • Sundstrom T
  • Bjerkvig R
  • Thorsen F.

Iterative methods for fast reconstruction of undersampled dynamic contrast-enhanced MRI data. In World Congress on Medical Physics and Biomedical Engineering 2018. (Book Chapter)

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
January 01, 2019
2019 Jan. Ibbott GS, Lhotska L, Sukupova L and Lackovic I, eds. Singapore: Springer Verlag, 2019. p.267-271. (IFMBE, Vol. 68, N°1). ISBN 978-981-10-9034-9 (print); 978-981-10-9035-6 (online).
By:
  • Walner H
  • Bartoš M
  • Mangová M
  • Keunen O
  • Bjerkvig R
  • Jiřík R
  • Šorel M.

Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
October 01, 2018
2018 Oct. J Cereb Blood Flow Metab.38(10):1741-1753. Epub 2017 Jun 19.
By:
  • Obad N
  • Espedal H
  • Jirik R
  • Sakariassen PO
  • Brekke Rygh C
  • Lund-Johansen M
  • Taxt T
  • Niclou SP
  • Bjerkvig R
  • Keunen O.

EGFL7 enhances surface expression of integrin alpha5beta1 to promote angiogenesis in malignant brain tumors.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Luxembourg Center of Neuropathology
September 01, 2018
2018 Sep. EMBO Mol Med.10(9).
By:
  • Dudvarski Stankovic N
  • Bicker F
  • Keller S
  • Jones DT
  • Harter PN
  • Kienzle A
  • Gillmann C
  • Arnold P
  • Golebiewska A
  • Keunen O
  • Giese A
  • von Deimling A
  • Bauerle T
  • Niclou SP
  • Mittelbronn M
  • Ye W
  • Pfister SM
  • Schmidt MHH.

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Computational Biomedicine
December 01, 2017
2017 Dec. EMBO Mol Med.9(12):1681-1695.
By:
  • Fack F
  • Tardito S
  • Hochart G
  • Oudin A
  • Zheng L
  • Fritah S
  • Golebiewska A
  • Nazarov PV
  • Bernard A
  • Hau AC
  • Keunen O
  • Leenders W
  • Lund-Johansen M
  • Stauber J
  • Gottlieb E
  • Bjerkvig R
  • Niclou SP.

Subtraction of subcutaneous fat to improve the prediction of visceral adiposity: exploring a new anthropometric track in overweight and obese youth.

  • Public Health Research
  • Translational Radiomics
  • Competence Center for Methodology and Statistics
August 01, 2017
2017 Aug. Pediatr Diabetes.18(5):399-404. Epub 2016 Jul 12.
By:
  • Samouda H
  • De Beaufort C
  • Stranges S
  • Van Nieuwenhuyse JP
  • Dooms G
  • Keunen O
  • Leite S
  • Vaillant M
  • Lair ML
  • Dadoun F.

EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
December 01, 2016
2016 Dec. Neuro Oncol.18(12):1644-1655. Epub 2016 Jun 10.
By:
  • Eskilsson E
  • Rosland GV
  • Talasila KM
  • Knappskog S
  • Keunen O
  • Sottoriva A
  • Foerster S
  • Solecki G
  • Taxt T
  • Jirik R
  • Fritah S
  • Harter PN
  • Valk K
  • Al Hossain J
  • Joseph JV
  • Jahedi R
  • Saed HS
  • Piccirillo SG
  • Spiteri I
  • Leiss L
  • Euskirchen P
  • Graziani G
  • Daubon T
  • Lund-Johansen M
  • Enger PO
  • Winkler F
  • Ritter CA
  • Niclou SP
  • Watts C
  • Bjerkvig R
  • Miletic H.

Cardiometabolic risk: leg fat is protective during childhood.

  • Public Health Research
  • Translational Radiomics
  • Competence Center for Methodology and Statistics
June 01, 2016
2016 Jun. Pediatr Diabetes.17(4):300-8. Epub 2015 Jun 17.
By:
  • Samouda H
  • De Beaufort C
  • Stranges S
  • Hirsch M
  • Van Nieuwenhuyse JP
  • Dooms G
  • Gilson G
  • Keunen O
  • Leite S
  • Vaillant M
  • Lair ML
  • Dadoun F.

Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Computational Biomedicine
  • Platform LUXGEN - Micro-array
  • Platform National Cytometry Platform
May 31, 2016
2016 May. Oncotarget.7(22):31955-71.
By:
  • Bougnaud S
  • Golebiewska A
  • Oudin A
  • Keunen O
  • Harter PN
  • Mader L
  • Azuaje F
  • Fritah S
  • Stieber D
  • Kaoma T
  • Vallar L
  • Brons NH
  • Daubon T
  • Miletic H
  • Sundstrom T
  • Herold-Mende C
  • Mittelbronn M
  • Bjerkvig R
  • Niclou SP.

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
December 01, 2015
2015 Dec. Nat Cell Biol.17(12):1556-68. Epub 2015 Nov 23.
By:
  • Tardito S
  • Oudin A
  • Ahmed SU
  • Fack F
  • Keunen O
  • Zheng L
  • Miletic H
  • Sakariassen PO
  • Weinstock A
  • Wagner A
  • Lindsay SL
  • Hock AK
  • Barnett SC
  • Ruppin E
  • Morkve SH
  • Lund-Johansen M
  • Chalmers AJ
  • Bjerkvig R
  • Niclou SP
  • Gottlieb E.

Epigenetic activity of peroxisome proliferator-activated receptor gamma agonists increases the anticancer effect of histone deacetylase inhibitors on multiple myeloma cells.

  • Tumor Immunotherapy and Microenvironment
  • Translational Radiomics
  • Laboratory of Oncolytic-Virus-Immuno-Therapeutics
June 19, 2015
2015 Jun. PLoS One.10(6):e0130339.
By:
  • Aouali N
  • Broukou A
  • Bosseler M
  • Keunen O
  • Schlesser V
  • Janji B
  • Palissot V
  • Stordeur P
  • Berchem G.

Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
January 01, 2015
2015 Jan. Acta Neuropathol.129(1):115-31. Epub 2014 Oct 17.
By:
  • Fack F
  • Espedal H
  • Keunen O
  • Golebiewska A
  • Obad N
  • Harter PN
  • Mittelbronn M
  • Bahr O
  • Weyerbrock A
  • Stuhr L
  • Miletic H
  • Sakariassen PO
  • Stieber D
  • Rygh CB
  • Lund-Johansen M
  • Zheng L
  • Gottlieb E
  • Niclou SP
  • Bjerkvig R.

Multimodal imaging of physiologic changes induced by anti-angiogenic therapy in glioblastoma. (Doctoral thesis)

  • NORLUX Neuro-Oncology Laboratory
December 18, 2014
2014 Dec. Bergen: University of Bergen, 2014. 56 (+ References) p.
By:
  • Keunen O.

Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies.

  • NORLUX Neuro-Oncology Laboratory
September 30, 2014
2014 Sep. Adv Drug Deliv Rev.76:98-115. Epub 2014 Jul 28.
By:
  • Keunen O
  • Taxt T
  • Gruner R
  • Lund-Johansen M
  • Tonn JC
  • Pavlin T
  • Bjerkvig R
  • Niclou SP
  • Thorsen F.

Bevacizumab treatment for human glioblastoma. Can it induce cognitive impairment?

  • NORLUX Neuro-Oncology Laboratory
May 01, 2014
2014 May. Neuro Oncol.16(5):754-6.
By:
  • Pakzad A
  • Obad N
  • Espedal H
  • Stieber D
  • Keunen O
  • Sakariassen PO
  • Niclou SP
  • Bjerkvig R.

The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status.

  • NORLUX Neuro-Oncology Laboratory
September 01, 2013
2013 Sep. Neuro Oncol.15(9):1200-11. Epub 2013 May 30.
By:
  • Johansson M
  • Oudin A
  • Tiemann K
  • Bernard A
  • Golebiewska A
  • Keunen O
  • Fack F
  • Stieber D
  • Wang B
  • Hedman H
  • Niclou SP.

EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis.

  • NORLUX Neuro-Oncology Laboratory
May 01, 2013
2013 May. Acta Neuropathol.125(5):683-98. Epub 2013 Feb 22.
By:
  • Talasila KM
  • Soentgerath A
  • Euskirchen P
  • Rosland GV
  • Wang J
  • Huszthy PC
  • Prestegarden L
  • Skaftnesmo KO
  • Sakariassen PO
  • Eskilsson E
  • Stieber D
  • Keunen O
  • Brekka N
  • Moen I
  • Nigro JM
  • Vintermyr OK
  • Lund-Johansen M
  • Niclou S
  • Mork SJ
  • Enger PO
  • Bjerkvig R
  • Miletic H.