Lecture - Dr Hiroshi Ohno - Integrated omics approach for understanding the gut ecosystem and dementia
26/01/2017 11:00 to 26/01/2017 14:00 (Europe/Luxembourg)
Animal gut is colonized with a huge number of commensal bacteria, collectively called gut microbiota; for example, the adult human colon hosts some 40 trillions of microbes classified into several hundred species. These microbes closely interact with each other and further with the host to establish the unique and complicated gut ecosystem, which deeply impacts our physiology and pathology including host defense and immunity. However, the underlying mechanisms of how gut ecosystem influences host defense and immune system have poorly understood. We have proposed an integrated omics approach, where different levels of exhaustive analyses such as (meta)genomics, (meta)transcriptomics and metabolomics are combined. By applying this approach, we have shown that Bifidobacterium-derived acetate can modify gene expression of the colonic epithelium to confer resistance against enterohemorrhagic Escherichia coli O157, which ultimately protects mice from O157-infectious death. We have also found that butyrate produced by the gut micirobiota can enhance differentiation of colonic regulatory T (Treg) cells from naïve T
cells, via epigenetic modification through its histone deacetylase inhibitory ability. Multiple sclerosis (MS) is a demyelinating disease. While its precise pahtogenesis is not clear, it is thought to be an autoimmune disorder including the host genetic factors and environmental factors; among the latter is the gut microbiota. We are studying experimental autoimmune encephalomyelitis (EAE), an animal model for MS with the integrated omics approach, and the results will also be discussed.
11:00 - 12:00 : LECTURE
Lycée Technique d'Esch/Alzette - Salle de projection audiovisuelle
12:30 - 14:00 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2017, followed by workshops especially dedicated to early-stage researchers.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.