Lecture - Novel concepts in tissue injury, remodeling, barrier and chronicity in allergic inflammation - Prof Cezmi A. Akdis
15/04/2016 13:00 to 15/04/2016 16:30 (Europe/Luxembourg)
The immune system is a highly interactive network, that makes its decisions on the basis of input from tissues, infections, normal flora bacteria and environmental agents. General rules of immunity-versustolerance apply to allergen-specific immune responses and these rules for regulators and effectors have probably been developed in a co-evolutionary manner with helminths, mites, insect venoms, foods and other allergens.This lecture will discuss the multiple proposed roles of tissues in immune regulation and chronicity in allergic inflammation. It will focus on group 2 innate lymphoid cells (ILC2s) localised on mucosal surfaces which are thought to play an essential role in regulation of tissue responses as well as in asthma development independently of the adaptive immune system. Bronchial epithelial leakiness has been shown to be involved in asthma, however the role of ILC2 in the regulation of bronchial epithelial tight junctions and barrier function was not known. The speaker will present recent in vitro and in vivo data demonstrating for the first time that ILC2s are able to disrupt the bronchial epithelial tight junction barrier as a novel mechanism in asthma pathogenesis.
13:00 - 14:30 : Lecture
Lycée Technique d'Esch/Alzette - Salle de projection audiovisuelle
15:00 - 16:30 : Workshop
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the workshop - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH lecture and workshops series in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2016, followed by workshops especially dedicated to early-stage researchers.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.