Lecture - Prof Gérard Eberl - "Regulation of inflammation by intestinal microbiota"
30/03/2017 11:30 to 30/03/2017 14:30 (Europe/Luxembourg)
The symbiotic microbiota represses the development of allergic inflammation, but the mechanisms involved are unclear. We have shown that intestinal bacteria induce the generation of type 3 T cells (Th17 cells and associated Tregs) that directly regulate pro-allergic type 2 T cells. In the absence of type 3 T cells, anti-helminth, but also pro-allergic responses, are exacerbated. Furthermore, the absence of microbiota during weaning has similar consequences on the deregulation of the immune system that last until adulthood, a phenomenon we name “imprinting”. We propose a model
of the immune system where different types of competing and mutually suppressive responses establish a healthy equilibrium. When this equilibrium is lost, because of an absence of one type of microbe in the environment, inflammatory pathology develops. Therapeutic strategies can be designed with the aim to restore immune equilibrium to counter immunopathology.
11:30 - 12:30 : LECTURE
Lycée Technique d'Esch/Alzette - Salle de projection audiovisuelle
13:00 - 14:30 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2017, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2017.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.