Lecture Series "Infection & Immunity" - Prof Klaus WARNATZ - "AUTOIMMUNITY IN IMMUNODEFICIENCY – WALKING ON A TIGHT ROPE"
14/06/2018 11:30 to 14/06/2018 14:30 (Europe/Luxembourg)
Autoimmunity is a leading clinical manifestation in patients with common variable immunodeficiency (CVID). About 30% of CVID patients suffer from overt autoimmunity and immune-mediated organ inflammation, which determine to a large extent the prognosis of these patients. Recent years allowed for better insight in the pathogenesis of this heterogeneous complication. While autoimmune cytopenias (Autoimmune hemolytic anemia and autoimmune thrombocytopenia) are predominantly B cell mediated, autoimmune enteropathy is mainly a problem of dysregulated T cell immunity. Interstitial lung disease seems to involve both arms of the adaptive immune system. Very little is known about the innate immune system in this context, but a strong association with an increased interferon signature has been postulated by several groups. Several monogenic causes are associated with the clinical presentation of CVID with secondary non-infectious complications adding to the picture. Finally, the first manuscripts demonstrate the contribution of a dysbalance in the gastrointestinal microbiome to the immune dysregulation in the affected patients. Thus, autoimmunity is the other side of the coin of immunodeficiency in a substantial group of CVID patients. We are still seeking a full picture of this complex immune dysregulation affected by genetic and non-genetic components in order to offer better treatment or even prevent these complications.
11:30 - 12:30 : LECTURE
Lycée Technique d'Esch/Alzette - Salle de projection audiovisuelle
13:00 - 14:30 : 'meet & eat'
House of BioHealth
Room Françoise Barré-Sinoussi
Registration required for the 'Meet & Eat' - send us an email.
About the Lecture & Workshop series - Infection & Immunity
The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2018, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2018.
Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.