PhD student in Immuno-Oncology - AM1120
1A-B, rue Thomas Edison, Strassen 1445, Luxembourg
Gliomas represent approximately 80% of all malignant tumours of the central nervous system. Among them, Glioblastoma (GBM) is the highest-grade glioma and the most common malignant brain tumour in adults. Despite established standard care of treatment, GBM recurrence is inevitable and prognosis remains poor with a median survival of 15 months after diagnosis. Hence, the development of novel therapeutic options, including immunotherapies, are needed. Importantly, GBM is a highly immunosuppressive cancer, where tumour-associated microglia/macrophages can constitute up to 30-40% of the tumour mass playing a key role in immune escape mechanisms. Thus, targeting these cells is emerging as a promising strategy for immunotherapy.
We aim to understand the role of tumour-associated microglia/macrophages along GBM progression with the goal to identify new prognostic markers and therapeutic targets.
Training and research Environment
The Neuro-Immunology Group belongs to the Department of Oncology, whose research activities focus on the cellular and molecular mechanisms of tumour progression using a wide range of cutting edge technologies, including genomics, transcriptomics and proteomics analyses, as well as in vitro and in vivo imaging modalities using both patient cohorts and state-of-the-art animal models for cancer research. The PhD student will be in charge of an Action LIONS funded project that aims to uncover targets to shift immune-suppressed TAMs into reactive cells in Glioblastoma.
KEY SKILLS, EXPERIENCE AND QUALIFICATIONS
- Master’s degree in Biomedical Sciences or Immunology. Prior experience in cancer research would be an advantage, but is not mandatory.
- Experience in cell culture, transcriptomics (scRNA-seq), confocal microscopy and flow-cytometry techniques.
Mouse experimentation practice and FELASA diploma (or equivalent) would be considered as an asset.
- Excellent time management, rigour, perseverance, scientific creativity and originality, writing skills, sense of priority and ability to work with others.
- Fluency in English is mandatory.
3-year fixed-term contract (renewable for 1 year) - Full time - Start date: January/February 2021
Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with universities and other research institutes.
Dr. Alessandro Michelucci, PhD
84 Val Fleuri
Additional information on the group can be found here : https://nig.lih.lu