Activities

The work of the Allergy and Clinical Immunology group has its focus on the common pathways leading to activation of immune reactions and induction of immune tolerance in various diseases, with special attention on IgE-mediated allergies.

Our goals are to identify and characterize novel insect venom allergens (in collaboration with Helmholtz Center, Munich) and to perform clinical-translational studies on anaphylaxis to various allergens (in collaboration with Odense Research Centre in Anaphylaxis/ORCA, University of Southern Denmark), but also on tolerance responses developing in patients undergoing allergen-specific immunotherapy (in collaboration with Centre Hospitalier de Luxembourg/CHL, Luxembourg). New targets for immune interventions and biomarkers for precision medicine will be developed and tested in pre-clinical models.

State-of-the-art techniques such as proteomics, CyTOF or gene network analysis are at our disposal to perform the studies.

Research projects

  • Molecular and clinical-translational studies on anaphylaxis (peanut, insect venom, wheat and fish).
  • Clinical-translational studies in patient cohorts with allergen-specific immunotherapy to insect venom, peanut and grass or birch pollen.
  • Assessment of novel targets for immunotherapy and experimental validation in murine models of allergy and immunotherapy.
  • Identification of biomarkers predicting the risk and the outcome of allergic disease and allergen-specific immunotherapy.

Featured Publications

Comprehensive mapping of immune tolerance yields a regulatory TNF receptor 2 signature in a murine model of successful Fel d 1-specific immunotherapy using high-dose CpG adjuvant.

  • Allergy and Clinical Immunology
December 20, 2020
2020 Dec. Allergy. Online ahead of print.
By:
  • Leonard C
  • Montamat G
  • Davril C
  • Domingues O
  • Hunewald O
  • Revets D
  • Guerin C
  • Blank S
  • Heckendorn J
  • Jardon G
  • Hentges F
  • Ollert M.

Protocol for a prospective, longitudinal cohort of people with COVID-19 and their household members to study factors associated with disease severity: the Predi-COVID study.

  • Deep Digital Phenotyping Research Unit
  • Integrated BioBank of Luxembourg
  • Competence Center for Methodology and Statistics
  • Public Health Expertise
  • Allergy and Clinical Immunology
  • Public Health Research
November 23, 2020
2020 Nov. BMJ Open.10(11):e041834.
By:
  • Fagherazzi G
  • Fischer A
  • Betsou F
  • Vaillant M
  • Ernens I
  • Masi S
  • Mossong J
  • Staub T
  • Brault D
  • Bahlawane C
  • Rashid MA
  • Ollert M
  • Gantenbein M
  • Huiart L.
See all publications

Contacts

Markus Ollert

M.D.

29, rue Henri Koch
L-4354Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-829