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Activities

Chronic lymphocytic leukemia is the most prevalent leukemia affecting adults and remains an incurable disease associated with a tumor-supportive microenvironment. Circulating leukemic cells accumulate in blood and lymphoid organs where they establish physical contacts with stromal cells. This cross-talk influences their homing to specific niches and the evolution of the disease. We study the role of several components of the microenvironment promoting disease progression (exosomes, hypoxia) on the functions of various bystander cells. Our use of in vitro systems and mouse models combined with a strong expertise on microRNA allow us to investigate in both fundamental and applied research topics (signaling, biomarkers).

Research projects

  • Regulation and role of miRNA in stroma-leukemic cells interactions.
  • Role of exosomes in the cross-talk between cancer cells and their microenvironment.
  • Influence of hypoxic stress on miRNA regulatory machinery.

Featured Publications

The tumor microenvironment-dependent transcription factors AHR and HIF-1α are dispensable for leukemogenesis in the Eµ-TCL1 mouse model of chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
September 08, 2021
2021 Sep. Cancers.13(18):4518.
By:
  • Gonder S
  • Largeot A
  • Gargiulo E
  • Pierson S
  • Fernandez Botana I
  • Pagano G
  • Paggetti J
  • Moussay E.

In vitro sensitivity to venetoclax and microenvironment protection in hairy cell leukemia.

  • Tumor Stroma Interactions
July 26, 2021
2021 Jul. Front Oncol.11:598319.
By:
  • Vereertbrugghen A
  • Colado A
  • Gargiulo E
  • Bezares RF
  • Fernandez Grecco H
  • Cordini G
  • Custidiano MDR
  • Francois JH
  • Berchem G
  • Borge M
  • Paggetti J
  • Moussay E
  • Gamberale R
  • Giordano M
  • Morande PE.
See all publications

Contacts

Etienne Moussay

Ph.D., ADR

84, rue Val Fleuri
L-1526Luxembourg
Luxembourg
Tel. : +352 26970-232